The young lions face Israel in Batumi, knowing they will secure a spot in Saturday’s final against Spain or Ukraine if they win.
But Aston Villa’s Ramsey will be out of the tournament after injuring his ankle in the quarter-final win over Portugal and eventually having to leave the stadium on crutches.
Full-backs Max Aarons and Ben Johnson are suspended after receiving too many yellow cards, meaning left-back Luke Thomas could come on.
Elsewhere, Anthony Gordon and Morgan Gibbs-White are expected to start again after stellar campaigns so far for Lee Carsley’s team.
Victory over the Czech Republic, Israel and Germany in the group stage was the first time England had won all three group stage matches at this tournament.
It also means they have a precedent for beating semi-final rivals Israel, whom they knocked out 2-0 last weekend thanks to goals from Arsenal’s Gordon and Emile Smith Rowe.
He has won the Under-21 Euro twice but has not lifted the trophy since 1984.
Expected England squad: Trafford; Garner, Harwood-Bellis, Colwill, Thomas; Smith Rowe, Gomes, Jones, Madueke; Gordon, Gibbs-White.